Genetics of Antiphospholipid Syndrome

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Genetics of Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is defined as recurrent arterial and/or venous thrombosis and obstetric complications in the presence of antiphospholipid antibodies (aPL). The possibility of a genetic predisposition to develop antiphospholipid syndrome (APS) and to produce anticardiolipin antibodies and lupus anticoagulant has been examined by family studies and population studies. Similar to m...

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Genetics of Antiphospholipid Syndrome

Antiphospholipid Syndrome (APS), also known as Hughes Syndrome in honor of the doctor who first described it, is an autoimmune disease characterized by clinical manifestations such as vascular thrombosis (both arterial and venous), and/or recurrent pregnancy loss along with the presence of persistently elevated antiphospholipid antibodies (aPL) titers in serum (Bertolaccini et al., 2006). The e...

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Anticardiolipin syndrome: antiphospholipid syndrome.

North Am 2000;26:215–27. 14 Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491–508. 15 Elkon KB. Apoptosis in SLE – too little or too much? Review. Clin Exp Rheumatol 1994;12:553–9. 16 Drappa J, Vaishnaw AK, Sullivan KE, Chu JL, Elkon KB. Fas gene-mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmu...

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Antiphospholipid syndrome

APS can be primary or secondary. Primary antiphospholipid syndrome occurs in the absence of any other related disease. Secondary antiphospholipid syndrome is often associated with systemic lupus erythematosus and less frequently with infections, drugs and other diseases. Serologic markers are antiphospholipid antibodies, lupus anticoagulant and anticardiolipin. In rare cases, APS leads to rapid...

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ژورنال

عنوان ژورنال: Human Genetics & Embryology

سال: 2011

ISSN: 2161-0436

DOI: 10.4172/2161-0436.1000e103